Scientists Discover Role Of APP In The Brain
AsianScientist (Apr. 23, 2014) – A research team in Singapore has uncovered a novel function of the amyloid precursor protein (APP), one of the main pathogenic culprits of Alzheimer’s disease. The study, published in Nature Communications , was led by Dr. Zeng Li at the National Neuroscience Institute (NNI) in Singapore, and involved investigators from Duke-NUS Graduate Medical School and the Agency for Science and Technology (A*STAR). Alzheimer’s disease is the most common form of dementia. While the exact cause of Alzheimer’s disease remains unknown, one of its pathological hallmarks – the clumping of APP product in the brain when the protein is abnormally processed – is clear. However, up till this point, little was known about the APP’s primary function in the brain. In the study, Zeng and her team discovered that APP can control the growth and maturation of newborn brain cells, which are critical for the maintenance of a healthy brain function. APP does this by regulating